Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Drosophila bendless catalyzes K63-linked polyubiquitination and is involved in the response to DNA damage.

Mutation research - 1 Mar 2018

Bai Zhiqiang, Li Zhouhua, Xiao Wei

Abstract excerpt

In this study, we report the identification and functional characterization of the Drosophila ben/ubc13 gene, encoding a unique ubiquitin-conjugating enzyme (Ubc or E2), in DNA-damage response. Ben forms a heterodimer with DmUev1a, the only Ubc/E2 variant (Uev) in Drosophila. Ben and DmUev1a act together to catalyze K63-linked polyubiquitination in vitro. ben can functionally rescue the yeast ubc13 null mutant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Damage
Share to Drosophila
Share to Drosophila Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lysine

Share to Sequence Homology

Share to Ubiquitin

Share to Ubiquitin-Conjugating Enzymes

Share to Ubiquitination

Source

Identifiers

PMID: 29518634
DOI: 10.1016/j.mrfmmm.2018.02.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Drosophila bendless catalyzes K63-linked polyubiquitination and is involved in the response to DNA damage.PMID 29518634Read ↗

Monoubiquitination of histone H2B is intrinsic to the Bre1 RING domain-Rad6 interaction and augmented by a second Rad6-binding site on Bre1.Semantic proximity Read ↗

The Drosophila bendless gene encodes a neural protein related to ubiquitin-conjugating enzymes.Semantic proximity Read ↗

bendless, a Drosophila gene affecting neuronal connectivity, encodes a ubiquitin-conjugating enzyme homolog.Semantic proximity Read ↗

Arabidopsis UEV1D promotes Lysine-63-linked polyubiquitination and is involved in DNA damage response.Semantic proximity Read ↗

Role of Doa1 in the Saccharomyces cerevisiae DNA damage response.Semantic proximity Read ↗

Interaction between RNF8 and DYRK2 is required for the recruitment of DNA repair molecules to DNA double-strand breaks.Semantic proximity Read ↗

Comprehensive approach to study branched ubiquitin chains reveals roles for K48-K63 branches in VCP/p97-related processesSemantic proximity Read ↗

Werner helicase-interacting protein 1 binds polyubiquitin via its zinc finger domain.Semantic proximity Read ↗

A ubiquitylation site in Cockayne syndrome B required for repair of oxidative DNA damage, but not for transcription-coupled nucleotide excision repair.Semantic proximity Read ↗

Drosophila MUS312 and the vertebrate ortholog BTBD12 interact with DNA structure-specific endonucleases in DNA repair and recombination.Semantic proximity Read ↗

The <i>Drosophila melanogaster</i> ortholog of RFWD3 functions independently of RAD51 during DNA repairSemantic proximity Read ↗

Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome StabilitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.