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Article

Mutant herpes simplex virus-mediated suppression of retinoblastoma.

Current eye research - 1 May 1999

Kogishi J, Miyatake S, Hangai M, Akimoto M, Okazaki K, Honda Y

Abstract excerpt

PURPOSE: To test the ability of a mutant herpes simplex virus (HSV) hrR3 to inhibit growth of Y79 human retinoblastoma in vitro and in vivo. METHODS: Cultured Y79 cells were infected with multiplicities of infection (MOI) ranging from 0.004 to 0.1 of hrR3. Surviving cells were counted using trypan blue dye exclusion. Using X-gal staining, expression of the lacZ gene was examined in vitro on day 3 postinfection to...

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PMID: 10372992
DOI: 10.1076/ceyr.18.5.321.5354

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