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Article

The herpes simplex virus type 1 ribonucleotide reductase is required for acute retinal disease.

Archives of virology - 1 Jan 1997

Brandt C R, Imesch P, Spencer B, Eliassi-Rad B, Syed N A, Untawale S, Robinson N L, Albert D M

Abstract excerpt

We have used a herpes simplex virus type 1 (HSV-1) ribonucleotide reductase (RR) null mutant (ICP6 delta) to determine if the HSV-1 RR is required for acute retinal disease. Injection of the ICP6 delta mutant into the vitreous induced mild transient signs of infection (vitreal infiltrate, retinal inflammation, and changes in retinal cytology). In contrast, the parental KOS and a revertant virus (ICP6 delta + 3.1)...

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Identifiers

PMID: 9191855
DOI: 10.1007/s007050050126

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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