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Article

Cell-cycle associated transcriptional regulation of ribonucleotide reductase in L1210 leukemia cells and drug-resistant variants.

Cancer communications - 1 Jan 1991

Johnson C E, Hughes K, Cory J G

Abstract excerpt

Previous studies from this laboratory have shown that the steady-state levels of the mRNA for the non-heme iron (NHI) subunit of ribonucleotide reductase were markedly elevated in hydroxyurea-resistant L1210 cell lines with minimal changes in the mRNA levels for the effector-binding (EB) subunit. In the present study, wild-type L1210 cells and their drug-resistant variants [hydroxyurea-resistant (HU-7);...

Topics

Animals
Blotting, Northern
Calcium
Cell Cycle
Deoxyadenosines
Drug Resistance
Egtazic Acid
Gene Expression Regulation, Neoplastic
Genetic Variation
Hydroxyurea
Kinetics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Leukemia L1210

Mice

Ribonucleotide Reductases

Transcription, Genetic

Tumor Cells, Cultured

Source

Identifiers

PMID: 1760249
DOI: 10.3727/095535491820873777

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1760249-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Cell-cycle associated transcriptional regulation of ribonucleotide reductase in L1210 leukemia cells and drug-resistant variants.PMID 1760249Read ↗

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