Expression of c-fos in human and murine multidrug-resistant cells.

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Article

Expression of c-fos in human and murine multidrug-resistant cells.

Molecular pharmacology - 1 Jul 1992

Bhushan A, Abramson R, Chiu J F, Tritton T R

Abstract excerpt

In both mouse sarcoma 180 and human KB cells selected for the multiple drug resistance (MDR) phenotype, there is an elevation in the steady state mRNA level of c-fos. There is no detectable gene amplification for c-fos, nor is there any significant change in the rate of mRNA transcription or degr...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 1
Animals
Antineoplastic Agents
Blotting, Northern
Cells, Cultured
Drug Resistance
Gene Expression Regulation, Neoplastic
Genes, fos
Genes, jun
Humans
Membrane Glycoproteins
Mice
Phenotype
Promoter Regions, Genetic
RNA, Messenger
Transcription, Genetic
Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 1353251

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1353251-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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