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Article

Mimicking phosphorylation of the small heat-shock protein alphaB-crystallin recruits the F-box protein FBX4 to nuclear SC35 speckles.

European journal of biochemistry - 1 Nov 2004

den Engelsman John, Bennink Erik J, Doerwald Linda, Onnekink Carla, Wunderink Lisa, Andley Usha P, Kato Kanefusa, de Jong Wilfried W, Boelens Wilbert C

Abstract excerpt

The mammalian small heat shock protein alphaB-crystallin can be phosphorylated at three different sites, Ser19, Ser45 and Ser59. We compared the intracellular distribution of wild-type, nonphosphorylatable and all possible pseudophosphorylation mutants of alphaB-crystallin by immunoblot and immunocytochemical analyses of stable and transiently transfected cells. We observed that pseudophosphorylation at two...

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Source

Identifiers

PMID: 15511225
DOI: 10.1111/j.1432-1033.2004.04359.x

Genes

CUL1
SKP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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