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Article

Enlargement of speckles of SF2/ASF due to loss of function of Smu1 is characterized in the mammalian temperature-sensitive mutant.

RNA biology - 1 Jan 2000

Sugaya Kimihiko, Ishihara Yoshie, Sugaya Keiko

Abstract excerpt

A temperature-sensitive (ts) CHO-K1 mutant cell line, tsTM18, exhibits chromosomal instability with decreased DNA synthesis at the nonpermissive temperature, 39 °C. An amino acid substitution in Smu1 underlying the ts phenotypes of tsTM18 cells was identified previously. We also found a ts defect in splicing of the unc52/perlecan gene. In the present study, we have generated cell lines expressing Smu1 tagged with...

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PMID: 21519198
DOI: 10.4161/rna.8.3.14656

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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