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Article

Effects on kidney disease, fertility and development in mice inheriting a protein-truncating Denys-Drash syndrome allele (Wt1tmT396).

Transgenic research - 1 Jun 2008

Patek Charles E, Brownstein David G, Fleming Stewart, Wroe Caroline, Rose Lorraine, Webb Anna, Berry Rachel L, Devenney Paul S, Walker Marion, Maddocks Oliver D K, Lawrence Nicola J, Harrison David J, Wood Katrina M, Miles Colin G, Hooper Martin L

Abstract excerpt

Denys-Drash syndrome (DDS) is caused by heterozygous mutations of the Wilms' tumour suppressor gene, WT1, characterised by early-onset diffuse mesangial sclerosis often associated with male pseudohermaphroditism and/or Wilms' tumourigenesis. Previously, we reported that the Wt1tmT396 allele induces DDS kidney disease in mice. In the present study heterozygotes (Wt1tmT396/+) were generated on inbred (129/Ola),...

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Identifiers

PMID: 18040647
DOI: 10.1007/s11248-007-9157-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Effects on kidney disease, fertility and development in mice inheriting a protein-truncating Denys-Drash syndrome allele (Wt1tmT396).PMID 18040647Read ↗

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