Article
Rat mesangial cells exhibit sex-specific profibrotic and proinflammatory phenotypes.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Jun 2009
Pawluczyk Izabella Z A, Tan Eddie K C, Harris Kevin P G
Abstract excerpt
BACKGROUND: Chronic renal disease progresses more rapidly in males compared to females. This study investigated whether there were any inherent differences between male and female mesangial cells that could contribute to this phenomenon and whether these differences could be modulated by sex hormones. METHODS: Experiments were carried out on cultured mesangial cells derived from adult male and female Wistar rat...
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