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Article

Using siRNA technique to generate transgenic animals with spatiotemporal and conditional gene knockdown.

The American journal of pathology - 1 Nov 2004

Chang Hung-Shu, Lin Ching-Hui, Chen Yu-Chi, Yu Winston C Y

Abstract excerpt

Based on the RNAi technique, we have developed a new approach that generates transgenic animals capable of mimicking human genetic diseases. The new system is a combination of siRNA with Cre-loxP and tetracycline-on. It has the characteristics of being stable, inheritable, and inducible, with the siRNA able to be transcribed tissue specifically. To support the ability of this new method to generate a model for a...

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Identifiers

PMID: 15509524
DOI: 10.1016/S0002-9440(10)63411-6
PMCID: PMC1618682

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ABCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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