[Transgenic mice as disease models].

Abstract excerpt

The methods used for making transgenic mice such as DNA microinjection in pronuclei, transformation of embryonic stem cells and production of chimeras, infection by retroviral vectors and sperm cells as carriers for foreign DNA are reported. Furthermore some characteristics of transgenic mice are mentioned, in particular factors influencing integration and expression of gene constructs. Different kinds of disease...

Topics

• Animals
• Disease Models, Animal
• Gene Expression Regulation
• Genetic Techniques
• Male
• Mice
• Mice, Transgenic
• Mutation
• RNA, Messenger
• Transfection
• Tumor Virus Infections