Article
T-cell properties determine disease site, clinical presentation, and cellular pathology of experimental autoimmune encephalomyelitis.
The American journal of pathology - 1 Nov 2004
Abromson-Leeman Sara, Bronson Rod, Luo Yi, Berman Michael, Leeman Rebecca, Leeman Joshua, Dorf Martin
Abstract excerpt
Two distinct clinical phenotypes of experimental autoimmune encephalomyelitis are observed in BALB interferon-gamma knockout mice immunized with encephalitogenic peptides of myelin basic protein. Conventional disease, characterized by ascending weakness and paralysis, occurs with greater frequency after immunizing with a peptide comprising residues 59 to 76. Axial-rotatory disease, characterized by uncontrolled...
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