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Article

The activation status of neuroantigen-specific T cells in the target organ determines the clinical outcome of autoimmune encephalomyelitis.

The Journal of experimental medicine - 19 Jan 2004

Kawakami Naoto, Lassmann Silke, Li Zhaoxia, Odoardi Francesca, Ritter Thomas, Ziemssen Tjalf, Klinkert Wolfgang E F, Ellwart Joachim W, Bradl Monika, Krivacic Kimberly, Lassmann Hans, Ransohoff Richard M, Volk Hans-Dieter, Wekerle Hartmut, Linington Christopher, Flügel Alexander

Abstract excerpt

The clinical picture of experimental autoimmune encephalomyelitis (EAE) is critically dependent on the nature of the target autoantigen and the genetic background of the experimental animals. Potentially lethal EAE is mediated by myelin basic protein (MBP)-specific T cells in Lewis rats, whereas transfer of S100beta- or myelin oligodendrocyte glycoprotein (MOG)-specific T cells causes intense inflammatory...

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Share to Encephalomyelitis, Autoimmune, Experimental

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Source

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Identifiers

PMID: 14734524
DOI: 10.1084/jem.20031064
PMCID: PMC2211765

Genes

MBP
MOG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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