Article
Adverse outcomes after preterm labor are associated with tumor necrosis factor-alpha polymorphism -863, but not -308, in mother-infant pairs.
American journal of obstetrics and gynecology - 1 Oct 2004
Amory Josephine H, Adams Kristina M, Lin Ming-Tseh, Hansen John A, Eschenbach David A, Hitti Jane
Abstract excerpt
OBJECTIVE: Two single-base polymorphisms of the tumor necrosis factor-alpha gene (TNF-alpha) at positions -863 and -308 are associated with variation in production of TNF-alpha (TNF-alpha). TNF-alpha genotypes were tested for association with adverse outcomes in mother-infant pairs with preterm labor. STUDY DESIGN: We analyzed a cohort of 118 mother-infant pairs with preterm labor before 34 weeks' gestation....
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