Article
Construction of a herpes simplex virus type 1 mutant with only a three-nucleotide change in the branchpoint region of the latency-associated transcript (LAT) and the stability of its two-kilobase LAT intron.
Journal of virology - 1 Nov 2004
Ng Alan K, Block Timothy M, Aiamkitsumrit Benjamas, Wang Mengjun, Clementi Emily, Wu Ting-Ting, Taylor John M, Su Ying-Hsiu
Abstract excerpt
Previous studies using a eukaryotic expression system indicated that the unusual stability of the latency-associated transcript (LAT) intron was due to its nonconsensus branchpoint sequence (T.-T Wu, Y.-H. Su, T. M. Block, and J. M. Taylor, Virology, 243:140-149, 1998). The present study investigated the role of the branchpoint sequence in the stability of the intron expressed from the herpes simplex virus type 1...
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