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Article

HSV LAT and neuronal survival.

International reviews of immunology - 1 Jan 2000

Bloom David C

Abstract excerpt

Herpes Simplex Virus (HSV) establishes a latent infection within sensory neurons and periodically reactivates in response to stress. HSV's ability to inhabit neurons for the life of the host involves a number of virally encoded functions that tightly regulate the latency-reactivation cycle, preventing uncontrolled spread of reactivating virus and large-scale death of neurons. The HSV latency-associated transcript...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14690860
DOI: 10.1080/08830180490265592

Genes

LAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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HSV LAT and neuronal survival.PMID 14690860Read ↗

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A LAT-associated function reduces productive-cycle gene expression during acute infection of murine sensory neurons with herpes simplex virus type 1Semantic proximity Read ↗

Two Small RNAs Encoded within the First 1.5 Kilobases of the Herpes Simplex Virus Type 1 Latency-Associated Transcript Can Inhibit Productive Infection and Cooperate To Inhibit ApoptosisSemantic proximity Read ↗

HSV-1 LAT Promoter Deletion Viruses Exhibit Strain-Specific and LAT-Dependent Epigenetic Regulation of Latent Viral Genomes in Human NeuronsSemantic proximity Read ↗

Herpes Simplex Virus 1 MicroRNA miR-H8 Is Dispensable for Latency and Reactivation In VivoSemantic proximity Read ↗

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