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Article

Methylation-associated PHOX2B gene silencing is a rare event in human neuroblastoma.

European journal of cancer (Oxford, England : 1990) - 1 Nov 2007

de Pontual Loïc, Trochet Delphine, Bourdeaut Franck, Thomas Sophie, Etchevers Heather, Chompret Agnes, Minard Véronique, Valteau Dominique, Brugieres Laurence, Munnich Arnold, Delattre Olivier, Lyonnet Stanislas, Janoueix-Lerosey Isabelle, Amiel Jeanne

Abstract excerpt

Neuroblastoma (NB), an embryonic tumour originating from neural crest cells, is one of the most common solid tumours in childhood. Although NB is characterised by numerous recurrent, large-scale chromosome rearrangements, the genes targeted by these imbalances have remained elusive. We recently identified the paired-like homeobox 2B (PHOX2B, MIM 603851) gene as disease-causing in dysautonomic disorders including...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17765533
DOI: 10.1016/j.ejca.2007.07.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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