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Article

The -1021C->T DBH gene variant is not associated with epilepsy or antiepileptic drug response.

Neurology - 26 Oct 2004

Depondt C, Cock H R, Healy D G, Burley M W, Weinshenker D, Wood N W, Goldstein D B, Sisodiya S M

Abstract excerpt

Dopamine beta-hydroxylase (DBH) catalyzes the conversion of dopamine to norepinephrine (NE). Animal studies show that genes in the NE pathway are candidates for susceptibility to epilepsy and antiepileptic drug (AED) response. The authors genotyped the -1021C-->T major functional polymorphism in the DBH gene in 675 patients with epilepsy and 1,087 controls. The authors found no association with epilepsy, several...

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Source

Identifiers

PMID: 15505174
DOI: 10.1212/01.wnl.0000142092.16719.ad

Genes

DBH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The -1021C->T DBH gene variant is not associated with epilepsy or antiepileptic drug response.PMID 15505174Read ↗

Lack of significant association between -1021C-->T polymorphism in the dopamine beta hydroxylase gene and attention deficit hyperactivity disorder.Semantic proximity Read ↗

A quantitative-trait analysis of human plasma-dopamine beta-hydroxylase activity: evidence for a major functional polymorphism at the DBH locus.Semantic proximity Read ↗

DBH -1021C>T and COMT Val108/158Met genotype are not associated with the P300 ERP in an auditory oddball task.Semantic proximity Read ↗

Haplotype-controlled analysis of the association of a non-synonymous single nucleotide polymorphism at DBH (+ 1603C --> T) with plasma dopamine beta-hydroxylase activity.Semantic proximity Read ↗

Genetic polymorphisms in SCN2A are not associated with epilepsy risk and AEDs response: evidence from a meta-analysis.Semantic proximity Read ↗

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Variants of Dopamine Beta Hydroxylase Gene Moderate Atomoxetine Response in Children with Attention-Deficit/Hyperactivity Disorder.Semantic proximity Read ↗

No evidence for allelic association between schizophrenia and a functional variant of the human dopamine beta-hydroxylase gene (DBH).Semantic proximity Read ↗

Mutations in the dopamine beta-hydroxylase gene are associated with human norepinephrine deficiency.Semantic proximity Read ↗

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Regulatory polymorphisms in human DBH affect peripheral gene expression and sympathetic activity.Semantic proximity Read ↗

[From gene to disease; dopamine-beta-hydroxylase deficiency and orthostatic hypotension].Semantic proximity Read ↗

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