Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

No evidence for allelic association between schizophrenia and a functional variant of the human dopamine beta-hydroxylase gene (DBH).

American journal of medical genetics - 15 Oct 1999

Williams H J, Bray N, Murphy K C, Cardno A G, Jones L A, Owen M J

Abstract excerpt

Dopamine beta-hydroxylase (DBH), the enzyme that converts dopamine to norepinepherine, has been proposed as being involved in the aetiology of schizophrenia. Previous work identified a functional polymorphism at nucleotide 910 of the DBH gene that results in a codon change in the mature protein Ala304Ser, with the mutant allele being associated with a lower enzymatic activity. In this study we performed an RFLP...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dopamine beta-Hydroxylase

Share to DBH gene

Share to Gene Frequency

Share to Genotype

Share to Polymorphism, Restriction Fragment Length

Share to Schizophrenia

Source

Identifiers

PMID: 10490716
DOI: 10.1002/(sici)1096-8628(19991015)88:5<557::aid-ajmg22>3.0.co;2-f

Genes

DBH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

No evidence for allelic association between schizophrenia and a functional variant of the human dopamine beta-hydroxylase gene (DBH).PMID 10490716Read ↗

No association between a putative functional promoter variant in the dopamine beta-hydroxylase gene and schizophrenia.Semantic proximity Read ↗

Lack of association between schizophrenia and polymorphisms in dopamine metabolism and transport genes.Semantic proximity Read ↗

Analysis of the polymorphic (GT)(n) repeat at the dopamine beta-hydroxylase gene in Spanish patients affected by schizophrenia.Semantic proximity Read ↗

Dopamine beta-hydroxylase (DBH) gene and schizophrenia phenotypic variability: a genetic association study.Semantic proximity Read ↗

Population genetics of a functional variant of the dopamine beta-hydroxylase gene (DBH).Semantic proximity Read ↗

Schizophrenia and the dopamine-beta-hydroxylase gene: results of a linkage and association study.Semantic proximity Read ↗

The -1021C->T DBH gene variant is not associated with epilepsy or antiepileptic drug response.Semantic proximity Read ↗

Haplotype-controlled analysis of the association of a non-synonymous single nucleotide polymorphism at DBH (+ 1603C --> T) with plasma dopamine beta-hydroxylase activity.Semantic proximity Read ↗

DRD4 dopamine receptor genotype and CSF monoamine metabolites in Finnish alcoholics and controls.Semantic proximity Read ↗

Dopamine beta-hydroxylase: two polymorphisms in linkage disequilibrium at the structural gene DBH associate with biochemical phenotypic variation.Semantic proximity Read ↗

Lack of association between dopamine-β hydroxylase gene and a history of suicide attempt in schizophrenia: comparison of molecular and statistical haplotype analyses.Semantic proximity Read ↗

A search for association between schizophrenia and dopamine-related alleles.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.