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Article

Regulatory polymorphisms in human DBH affect peripheral gene expression and sympathetic activity.

Circulation research - 5 Dec 2014

Barrie Elizabeth S, Weinshenker David, Verma Anurag, Pendergrass Sarah A, Lange Leslie A, Ritchie Marylyn D, Wilson James G, Kuivaniemi Helena, Tromp Gerard, Carey David J, Gerhard Glenn S, Brilliant Murray H, Hebbring Scott J, Cubells Joseph F, Pinsonneault Julia K, Norman Greg J, Sadee Wolfgang

Abstract excerpt

RATIONALE: Dopamine β-hydroxylase (DBH) catalyzes the conversion of dopamine to norepinephrine in the central nervous system and peripherally. DBH variants are associated with large changes in circulating DBH and implicated in multiple disorders; yet causal relationships and tissue-specific effects remain unresolved. OBJECTIVE: To characterize regulatory variants in DBH, effect on mRNA expression, and role in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25326128
DOI: 10.1161/CIRCRESAHA.116.304398
PMCID: PMC4258174

Genes

DBH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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