Article
In vivo assessment of drug efficacy against Plasmodium falciparum malaria: duration of follow-up.
Antimicrobial agents and chemotherapy - 1 Nov 2004
Stepniewska Kasia, Taylor Walter R J, Mayxay Mayfong, Price Ric, Smithuis Frank, Guthmann Jean-Paul, Barnes Karen, Myint Hla Yin, Adjuik Martin, Olliaro Piero, Pukrittayakamee Sasithon, Looareesuwan Sornchai, Hien Tran Tinh, Farrar Jeremy, Nosten François, Day Nicholas P J, White Nicholas J
Abstract excerpt
To determine the optimum duration of follow-up for the assessment of drug efficacy against Plasmodium falciparum malaria, 96 trial arms from randomized controlled trials (RCTs) with follow-up of 28 days or longer that were conducted between 1990 and 2003 were analyzed. These trials enrolled 13,772 patients, and participating patients comprised 23% of all patients enrolled in RCTs over the past 40 years; 61 (64%)...
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