Article
In vivo efficacy of artemether-lumefantrine and chloroquine against Plasmodium vivax: a randomized open label trial in central Ethiopia.
PloS one - 1 Jan 2013
Hwang Jimee, Alemayehu Bereket Hailegiorgis, Reithinger Richard, Tekleyohannes Samuel Girma, Takele Teshi, Birhanu Sintayehu Gebresillasie, Demeke Leykun, Hoos David, Melaku Zenebe, Kassa Moges, Jima Daddi, Malone Joseph L, Nettey Henry, Green Michael, Poe Amanda, Akinyi Sheila, Udhayakumar Venkatachalam, Kachur S Patrick, Filler Scott
Abstract excerpt
BACKGROUND: In vivo efficacy assessments of antimalarials are essential for ensuring effective case management. In Ethiopia, chloroquine (CQ) without primaquine is the first-line treatment for Plasmodium vivax in malarious areas, but artemether-lumefantrine (AL) is also commonly used. METHODS AND FINDINGS: In 2009, we conducted a 42-day efficacy study of AL or CQ for P. vivax in Oromia Regional State, Ethiopia....
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