Article
Methodological issues in the assessment of antimalarial drug treatment: analysis of 13 studies in eight African countries from 2001 to 2004.
Antimicrobial agents and chemotherapy - 1 Nov 2006
Guthmann Jean-Paul, Pinoges Loretxu, Checchi Francesco, Cousens Simon, Balkan Suna, van Herp Michel, Legros Dominique, Olliaro Piero
Abstract excerpt
The objectives of these analyses were to assess the feasibility of the latest WHO recommendations (28-day follow-up with PCR genotyping) for the assessment of antimalarial drug efficacy in vivo and to examine how different statistical approaches affect results. We used individual-patient data from 13 studies of uncomplicated pediatric falciparum malaria conducted in sub-Saharan Africa, using chloroquine (CQ),...
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