Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Anti-termination by SIV Tat requires flexibility of the nascent TAR structure.

Journal of molecular biology - 12 Nov 2004

Sommer Peter, Vartanian Jean-Pierre, Wachsmuth Malte, Henry Michel, Guetard Denise, Wain-Hobson Simon

Abstract excerpt

Substitution of the SIVmac239 promoter/enhancer by the strong EF1alpha promoter results in a severe replication defect due to a failure to respond to Tat. Revertant viruses with minimal promoter sequences (two Sp1 sites and a TATA box) were obtained that had fully restored their replicative potential. Comparison of the different LTRs indicated that structural alterations in the TAR stem due to a 31bp exon of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Products, tat
Share to HIV
Share to Jurkat Cells

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Peptide Elongation Factor 1

Share to Simian Immunodeficiency Virus

Share to tat Gene Products, Human Immunodeficiency Virus

Share to Terminal Repeat Sequences

Share to Transcriptional Activation

Source

Identifiers

PMID: 15504399
DOI: 10.1016/j.jmb.2004.09.042

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Anti-termination by SIV Tat requires flexibility of the nascent TAR structure.PMID 15504399Read ↗

Functional analysis of the complex trans-activating response element RNA structure in simian immunodeficiency virus.Semantic proximity Read ↗

The Structure of the Human Immunodeficiency Virus Type-1 TAR RNA Reveals Principles of RNA Recognition by Tat ProteinSemantic proximity Read ↗

Efficient transcription through an intron requires the binding of an Sm-type U1 snRNP with intact stem loop II to the splice donor.Semantic proximity Read ↗

The apical loop of the HIV-1 TAR RNA hairpin is stabilized by a cross-loop base pair.Semantic proximity Read ↗

Opening of the TAR hairpin in the HIV-1 genome causes aberrant RNA dimerization and packaging.Semantic proximity Read ↗

Human immunodeficiency virus type 1 TAR element revertant viruses define RNA structures required for efficient viral gene expression and replication.Semantic proximity Read ↗

The 5' and 3' TAR elements of human immunodeficiency virus exert effects at several points in the virus life cycle.Semantic proximity Read ↗

Structural requirements for trans activation of human immunodeficiency virus type 1 long terminal repeat-directed gene expression by tat: importance of base pairing, loop sequence, and bulges in the tat-responsive sequence.Semantic proximity Read ↗

Repair of a Rev-minus human immunodeficiency virus type 1 mutant by activation of a cryptic splice site.Semantic proximity Read ↗

A nuclear translational block imposed by the HIV-1 U3 region is relieved by the Tat-TAR interaction.Semantic proximity Read ↗

Destabilization of the TAR hairpin leads to extension of the polyA hairpin and inhibition of HIV-1 polyadenylationSemantic proximity Read ↗

The human immunodeficiency virus type 1 TAR RNA upper stem-loop plays distinct roles in reverse transcription and RNA packaging.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.