Article
[Hammerhead ribozyme against human telomerase catalytic subunit (hTERT) induced apoptosis of liver cancer cells].
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology - 1 Oct 2004
Song Dong-po, Lin Ju-sheng, Fu Gui-lian, Sun Xue-mei, Kong Xin-juan, Li Pei-yuan, Ma Xin
Abstract excerpt
OBJECTIVE: To construct vector pEGFP-C1-hTERT-ribozyme (pGTRz-U6) and its mutant (pGTmRz-U6) against hTERT containing U6 promoter, then transfect them into human liver cancer cell line SMMC7721 to observe the action of the human telomerase catalytic subunit (hTERT) hammerhead ribozyme on proliferation and apoptosis of human liver cancer cell SMMC7721. METHODS: Eukaryotic expressing vector pGTRz-U6 and mutant...
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