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Article

Adenovirus-mediated Suicide Gene Therapy Using the Human Telomerase Catalytic Subunit (hTERT) Gene Promoter Induced Apoptosis of Ovarian Cancer Cell Line

1 Jan 2003

Abstract excerpt

Telomerase is a ribonucleoprotein complex the function of which is to add telomeric repeats (TTAGGG)(n) to chromosomal ends, and it is known to play an important role in cellular immortalization. Telomerase is highly active in most tumor cells, yet not in normal cells. As such, it may have possible applications in cancer gene therapy. Telomerase consists of two essential components, telomerase RNA template (hTR)...

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Identifiers

PMID: 14646192
DOI: 10.1271/bbb.67.2344

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