Article
Targeting mortalin using conventional and RNA-helicase-coupled hammerhead ribozymes.
EMBO reports - 1 Jun 2003
Wadhwa Renu, Ando Hiroshi, Kawasaki Hiroaki, Taira Kazunari, Kaul Sunil C
Abstract excerpt
Mortalin, also known as mot2/mthsp70/GRP75/PBP74, is a member of the heat-shock protein 70 family that is heat-uninducible. It is differentially distributed in cells that have normal and immortal phenotypes, has been localized to various subcellular sites, and has several binding partners and functions. Here, we describe the construction and use of mortalin-specific conventional and hybrid ribozymes to elucidate...
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