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Article

Epistatic interactions modulate the evolution of mammalian mitochondrial respiratory complex components.

BMC genomics - 13 Jun 2009

Azevedo Luísa, Carneiro João, van Asch Barbara, Moleirinho Ana, Pereira Filipe, Amorim António

Abstract excerpt

BACKGROUND: The deleterious effect of a mutation can be reverted by a second-site interacting residue. This is an epistatic compensatory process explaining why mutations that are deleterious in some species are tolerated in phylogenetically related lineages, rendering evident that those mutations are, by all means, only deleterious in the species-specific context. Although an extensive and refined theoretical...

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Share to Electron Transport Complex III

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Structure, Tertiary

Source

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Identifiers

PMID: 19523237
DOI: 10.1186/1471-2164-10-266
PMCID: PMC2711975

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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