Functional recurrent mutations in the human mitochondrial phylogeny: dual roles in evolution and disease.

Abstract excerpt

Mutations frequently reoccur in the human mitochondrial DNA (mtDNA). However, it is unclear whether recurrent mtDNA nodal mutations (RNMs), that is, recurrent mutations in stems of unrelated phylogenetic nodes, are functional and hence selectively constrained. To answer this question, we performed comprehensive parsimony and maximum likelihood analyses of 9,868 publicly available whole human mtDNAs revealing...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Codon
• Share to DNA, Mitochondrial
• Share to Evolution, Molecular