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Article

Acetate-mediated production of orotic acid by ura3 mutants of Candida albicans.

Microbiology and immunology - 1 Jan 2004

Nezu Takashi, Shimokawa Osamu

Abstract excerpt

Candida albicans ura3 mutants were found to produce large amounts of orotic acid when the growth medium was supplemented with sodium acetate. Experiments with 13C-labeled acetate showed that the acetate served as a precursor of orotic acid. This system of acetate-mediated production of orotic acid is similar to other documented microbial producers in yield but unique for its acetate requirement.

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PMID: 15502413
DOI: 10.1111/j.1348-0421.2004.tb03595.x

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