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[Screening and characteristics of mutants of E. coli resistant to acetate inhibition].

Wei sheng wu xue bao = Acta microbiologica Sinica - 1 Apr 2001

Li Z, Ye Q

Abstract excerpt

Acetate is accumulated in the aerobic high cell density culture of Escherichia coli, Which seriously inhibits cell growth and expression of recombinant proteins. To alleviate acetate inhibition, mutants of E. coli JM101 were generated by 60Co radiation and then enriched in continuous culture with acetate as the selective pressure. One of the mutants isolated, JL3, showed obvious increased tolerance toward acetate...

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PMID: 12549030

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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