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Article

Production of orotic acid by a Klura3Δ mutant of Kluyveromyces lactis.

Journal of bioscience and bioengineering - 1 Jun 2016

Carvalho Nuno, Coelho Eduardo, Gales Luís, Costa Vítor, Teixeira José António, Moradas-Ferreira Pedro

Abstract excerpt

We demonstrated that a Klura3Δ, mutant of the yeast Kluyveromyces lactis is able to produce and secrete into the growth medium considerable amounts of orotic acid. Using yeast extract-peptone-glucose (YPD) based media we optimized production conditions in flask and bioreactor cultures. With cells grown in YPD 5% glucose medium, the best production in flask was obtained with a 1:12.5 ratio for flask: culture...

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PMID: 26707627
DOI: 10.1016/j.jbiosc.2015.10.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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