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Article

A chromosome 21 critical region does not cause specific Down syndrome phenotypes.

Science (New York, N.Y.) - 22 Oct 2004

Olson L E, Richtsmeier J T, Leszl J, Reeves R H

Abstract excerpt

The "Down syndrome critical region" (DSCR) is a chromosome 21 segment purported to contain genes responsible for many features of Down syndrome (DS), including craniofacial dysmorphology. We used chromosome engineering to create mice that were trisomic or monosomic for only the mouse chromosome s...

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Identifiers

PMID: 15499018
DOI: 10.1126/science.1098992
PMCID: PMC4019810

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15499018-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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