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Genetic dissection of Down syndrome-associated congenital heart defects using a new mouse mapping panel

14 Jan 2016

Abstract excerpt

Down syndrome (DS), caused by trisomy of human chromosome 21 (Hsa21), is the most common cause of congenital heart defects (CHD), yet the genetic and mechanistic causes of these defects remain unknown. To identify dosage-sensitive genes that cause DS phenotypes, including CHD, we used chromosome engineering to generate a mapping panel of 7 mouse strains with partial trisomies of regions of mouse chromosome 16...

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PMID: 26765563
DOI: 10.7554/elife.11614

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