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Article

Too much of a good thing: mechanisms of gene action in Down syndrome.

Trends in genetics : TIG - 1 Feb 2001

Reeves R H, Baxter L L, Richtsmeier J T

Abstract excerpt

The molecular mechanisms underlying the specific traits in individuals with Down syndrome (DS) have been postulated to derive either from nonspecific perturbation of balanced genetic programs, or from the simple, mendelian-like influence of a small subset of genes on chromosome 21. However, these models do not provide a comprehensive explanation for experimental or clinical observations of the effects of trisomy...

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PMID: 11173117
DOI: 10.1016/s0168-9525(00)02172-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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