Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular genetic analysis of Down syndrome.

Human genetics - 1 Jul 2009

Patterson David

Abstract excerpt

Down syndrome (DS) is caused by trisomy of all or part of human chromosome 21 (HSA21) and is the most common genetic cause of significant intellectual disability. In addition to intellectual disability, many other health problems, such as congenital heart disease, Alzheimer's disease, leukemia, hypotonia, motor disorders, and various physical anomalies occur at an elevated frequency in people with DS. On the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Trisomy
Share to Chromosomes, Human, Pair 21
Share to Down Syndrome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Dosage

Share to MicroRNAs

Share to Models, Animal

Share to Mosaicism

Share to Proteome

Source

Identifiers

PMID: 19526251
DOI: 10.1007/s00439-009-0696-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular genetic analysis of Down syndrome.PMID 19526251Read ↗

Mouse-based genetic modeling and analysis of Down syndromeSemantic proximity Read ↗

Down syndrome--recent progress and future prospectsSemantic proximity Read ↗

The power of comparative and developmental studies for mouse models of Down syndrome.Semantic proximity Read ↗

Down syndrome: searching for the genetic culpritsSemantic proximity Read ↗

Trisomy 21 and Down syndrome: a short review.Semantic proximity Read ↗

Down syndrome mouse models are looking up.Semantic proximity Read ↗

A non-mosaic transchromosomic mouse model of Down syndrome carrying the long arm of human chromosome 21Semantic proximity Read ↗

Rodent models in Down syndrome research: impact and future opportunities.Semantic proximity Read ↗

All Creatures Great and Small: New Approaches for Understanding Down Syndrome GeneticsSemantic proximity Read ↗

A non-mosaic humanized mouse model of Down syndrome, trisomy of a nearly complete long arm of human chromosome 21 in mouse chromosome backgroundSemantic proximity Read ↗

Using mouse models to explore genotype-phenotype relationship in Down syndrome.Semantic proximity Read ↗

Molecular mapping of the Down syndrome phenotype on chromosome 21.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.