Article
Identification of a DNA nonhomologous end-joining complex in bacteria.
Science (New York, N.Y.) - 6 Sept 2002
Weller Geoffrey R, Kysela Boris, Roy Rajat, Tonkin Louise M, Scanlan Elizabeth, Della Marina, Devine Susanne Krogh, Day Jonathan P, Wilkinson Adam, d'Adda di Fagagna Fabrizio, Devine Kevin M, Bowater Richard P, Jeggo Penny A, Jackson Stephen P, Doherty Aidan J
Abstract excerpt
In eukaryotic cells, double-strand breaks (DSBs) in DNA are generally repaired by the pathway of homologous recombination or by DNA nonhomologous end joining (NHEJ). Both pathways have been highly conserved throughout eukaryotic evolution, but no equivalent NHEJ system has been identified in prok...
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