Article
A cluster of metabolic defects caused by mutation in a mitochondrial tRNA.
Science (New York, N.Y.) - 12 Nov 2004
Wilson Frederick H, Hariri Ali, Farhi Anita, Zhao Hongyu, Petersen Kitt Falk, Toka Hakan R, Nelson-Williams Carol, Raja Khalid M, Kashgarian Michael, Shulman Gerald I, Scheinman Steven J, Lifton Richard P
Abstract excerpt
Hypertension and dyslipidemia are risk factors for atherosclerosis and occur together more often than expected by chance. Although this clustering suggests shared causation, unifying factors remain unknown. We describe a large kindred with a syndrome including hypertension, hypercholesterolemia, and hypomagnesemia. Each phenotype is transmitted on the maternal lineage with a pattern indicating mitochondrial...
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