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Article

Null mutations in human and mouse orthologs frequently result in different phenotypes.

Proceedings of the National Academy of Sciences of the United States of America - 13 May 2008

Liao Ben-Yang, Zhang Jianzhi

Abstract excerpt

One-to-one orthologous genes of relatively closely related species are widely assumed to have similar functions and cause similar phenotypes when deleted from the genome. Although this assumption is the foundation of comparative genomics and the basis for the use of model organisms to study human...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18458337
DOI: 10.1073/pnas.0800387105
PMCID: PMC2383943

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18458337-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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