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Article

Repair of damaged DNA by extracts from a xeroderma pigmentosum complementation group A revertant and expression of a protein absent in its parental cell line.

Nucleic acids research - 11 Mar 1992

Jones C J, Cleaver J E, Wood R D

Abstract excerpt

Cells derived from individuals with mutations in the xeroderma pigmentosum complementation group A gene (XP-A gene) are hypersensitive to UV light and have a severe defect in nucleotide excision repair of damaged DNA. UV-resistant revertant cell lines can arise from XP-A cells in culture. Cells of one such revertant, XP129, were previously shown to remove (6-4) photoproducts from irradiated DNA, but to have poor...

Topics

Amino Acid Sequence
Cell Extracts
Cell Line
DNA Damage
DNA Repair
DNA-Binding Proteins
Genetic Complementation Test
Humans
Immunoblotting
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Xeroderma Pigmentosum

Xeroderma Pigmentosum Group A Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 1549511
DOI: 10.1093/nar/20.5.991
PMCID: PMC312081

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1549511-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Repair of damaged DNA by extracts from a xeroderma pigmentosum complementation group A revertant and expression of a protein absent in its parental cell line.PMID 1549511Read ↗

Mutation and expression of the XPA gene in revertants and hybrids of a xeroderma pigmentosum cell line.Semantic proximity Read ↗

XP-A cells complemented with Arg228Gln and Val234Leu polymorphic XPA alleles repair BPDE-induced DNA damage better than cells complemented with the wild type allele.Semantic proximity Read ↗

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UV-sensitive rodent mutant cell lines of complementation groups 6 and 8 differ phenotypically from their human counterparts.Semantic proximity Read ↗

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