Article
Functional complementation of xeroderma pigmentosum complementation group E by replication protein A in an in vitro system.
Proceedings of the National Academy of Sciences of the United States of America - 14 May 1996
Kazantsev A, Mu D, Nichols A F, Zhao X, Linn S, Sancar A
Abstract excerpt
Xeroderma pigmentosum (XP) is caused by a defect in nucleotide excision repair. Patients in the complementation group E (XP-E) have the mildest form of the disease and the highest level of residual repair activity. About 20% of the cell strains derived from XP-E patients lack a damaged DNA-bindin...
Topics
- Base Sequence
- Cell-Free System
- DNA Damage
- DNA Repair
- DNA, Complementary
- DNA-Binding Proteins
- Escherichia coli
- Genetic Complementation Test
- HeLa Cells
- Humans
- In Vitro Techniques
- Molecular Sequence Data
- Mutation
- Recombinant Proteins
- Replication Protein A