Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional complementation of xeroderma pigmentosum complementation group E by replication protein A in an in vitro system.

Proceedings of the National Academy of Sciences of the United States of America - 14 May 1996

Kazantsev A, Mu D, Nichols A F, Zhao X, Linn S, Sancar A

Abstract excerpt

Xeroderma pigmentosum (XP) is caused by a defect in nucleotide excision repair. Patients in the complementation group E (XP-E) have the mildest form of the disease and the highest level of residual repair activity. About 20% of the cell strains derived from XP-E patients lack a damaged DNA-binding protein (DDB) activity that binds to ultraviolet-induced (6-4) photoproducts with high affinity. We report here that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to DNA-Binding Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA, Complementary

Share to Escherichia coli

Share to Genetic Complementation Test

Share to Molecular Sequence Data

Share to Mutation

Share to Recombinant Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 8643521
DOI: 10.1073/pnas.93.10.5014
PMCID: PMC39398

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional complementation of xeroderma pigmentosum complementation group E by replication protein A in an in vitro system.PMID 8643521Read ↗

Functional studies on the interaction between human replication protein A and Xeroderma pigmentosum group A complementing protein (XPA).Semantic proximity Read ↗

Do we know the cause of xeroderma pigmentosum?Semantic proximity Read ↗

True XP group E patients have a defective UV-damaged DNA binding protein complex and mutations in DDB2 which reveal the functional domains of its p48 product.Semantic proximity Read ↗

Complementation of the DNA repair deficiency in human xeroderma pigmentosum group a and C cells by recombinant adenovirus-mediated gene transfer.Semantic proximity Read ↗

Repair of damaged DNA by extracts from a xeroderma pigmentosum complementation group A revertant and expression of a protein absent in its parental cell line.Semantic proximity Read ↗

Reinvestigation of the classification of five cell strains of xeroderma pigmentosum group E with reclassification of three of them.Semantic proximity Read ↗

An Interaction between the DNA Repair Factor XPA and Replication Protein A Appears Essential for Nucleotide Excision RepairSemantic proximity Read ↗

Nucleotide excision repair proteins rapidly accumulate but fail to persist in human XP-E (DDB2 mutant) cells.Semantic proximity Read ↗

Cockayne syndrome complementation group B associated with xeroderma pigmentosum phenotype.Semantic proximity Read ↗

A simple method for diagnosing xeroderma pigmentosum variant.Semantic proximity Read ↗

DDB Accumulates at DNA Damage Sites Immediately after UV Irradiation and Directly Stimulates Nucleotide Excision RepairSemantic proximity Read ↗

Evidence for a repair enzyme complex involving ERCC1 and complementing activities of ERCC4, ERCC11 and xeroderma pigmentosum group F.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.