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Article

Inhibition of monocyte chemoattractant protein-1 ameliorates rat adjuvant-induced arthritis.

Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 2008

Shahrara Shiva, Proudfoot Amanda E I, Park Christy C, Volin Michael V, Haines G Kenneth, Woods James M, Aikens Christopher H, Handel Tracy M, Pope Richard M

Abstract excerpt

Chemokines, including RANTES/CCL5 and MCP-1/CCL2, are highly expressed in the joints of patients with rheumatoid arthritis, and they promote leukocyte migration into the synovial tissue. This study was conducted to determine whether the inhibition of RANTES and MCP-1 therapeutically was capable of ameliorating rat of adjuvant-induced arthritis (AIA). Postonset treatment of AIA using a novel inhibitor for...

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Share to Adjuvants, Immunologic
Share to Arthritis, Experimental

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chemokine CCL2

Share to Chemokine CCL5

Share to Collagen

Share to Injections, Intraperitoneal

Share to Rats, Inbred Lew

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Source

Identifiers

PMID: 18292571
DOI: 10.4049/jimmunol.180.5.3447

Genes

CCL2
CCL5
CCR1
CCR5
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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