Article
Phenotypic variation in cardiovascular responses to acute hypoxic and hypercapnic exposure in mice.
Physiological genomics - 15 Dec 2004
Campen Matthew J, Tagaito Yugo, Li Jianguo, Balbir Alexander, Tankersley Clarke G, Smith Phillip, Schwartz Alan, O'Donnell Christopher P
Abstract excerpt
The impact of genetic variation on cardiovascular responses to hypoxia and hypercapnia is not well understood. Therefore, we determined the acute changes in systemic arterial blood pressure (P(SA)) and heart rate (HR) in seven strains of commonly used inbred mice exposed to acute periods of hypoxia (10% O(2)), hypercapnia (5% CO(2)), and hypoxia/hypercapnia (10% O(2) + 5% CO(2)) during wakefulness. Hypercapnia...
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