Article
Heritable differences in respiratory drive and breathing pattern in mice during anaesthesia and emergence.
British journal of anaesthesia - 1 Oct 2003
Groeben H, Meier S, Tankersley C G, Mitzner W, Brown R H
Abstract excerpt
BACKGROUND: Postanaesthetic hypoxia and ischaemia can lead to postoperative morbidity and mortality. We studied the effect of isoflurane anaesthesia in two inbred mouse strains known for phenotypic differences in breathing pattern and respiratory drive during carbon dioxide challenge and their first-generation offspring (F(1)). METHODS: Using whole body plethysmography, we assessed respiratory rate (RR) and...
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