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Structural models for the design of novel antiviral agents against Greek Goat Encephalitis

6 Nov 2014

Abstract excerpt

The Greek Goat Encephalitis virus (GGE) belongs to the Flaviviridae family of the genus Flavivirus. The GGE virus constitutes an important pathogen of livestock that infects the goat's central nervous system. The viral enzymes of GGE, helicase and RNA-dependent RNA polymerase (RdRP), are ideal targets for inhibitor design, since those enzymes are crucial for the virus' survival, proliferation and transmission. In...

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PMID: 25392762
DOI: 10.7717/peerj.664

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