Disruption of microtubules leads to glucocorticoid receptor degradation in HeLa cell line.

Abstract excerpt

The role of microtubules (MTs) in steroid hormone-dependent human glucocorticoid receptor (hGR) activation/translocation is controversial. It was demonstrated recently that colchicine (COL) down-regulates hGR-driven genes in primary human hepatocytes by a mechanism involving inhibition of hGR translocation to the nucleus. To investigate whether inhibition of hGR translocation is the sole reason for its...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Leupeptins
• Share to Anthracenes
• Share to Colchicine