Article
Hormonal regulation of the nuclear localization signals of the human glucocorticosteroid receptor.
Experimental cell research - 1 Jul 1992
Cadepond F, Gasc J M, Delahaye F, Jibard N, Schweizer-Groyer G, Segard-Maurel I, Evans R, Baulieu E E
Abstract excerpt
Nuclear localization of the rat glucocorticosteroid receptor (rGR) transiently expressed in COS-7 cells appears to be mediated by two nuclear localization signals, NL1 and NL2, in a hormone-dependent mechanism. We investigated the intracellular distribution of the human GR (hGR) expressed in COS-...
Topics
- Cell Line
- Cell Nucleus
- Cysteine
- Cytoplasm
- DNA
- Humans
- Immunohistochemistry
- Ligands
- Phenotype
- Receptors, Glucocorticoid
- Transcription, Genetic