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Article

PTEN mutations do not cause nuclear beta-catenin accumulation in endometrial carcinomas.

Human pathology - 1 Oct 2004

Wappenschmidt B, Wardelmann E, Gehrig A, Schöndorf T, Maass N, Bonatz G, Gassel A-M, Pietsch T, Mallmann P, Weber B H F, Schmutzler R K

Abstract excerpt

PTEN: and beta-catenin mutations constitute the predominant genetic alterations in endometrioid carcinomas of the endometrium. PTEN encodes a dual-specificity phosphatase with lipid phosphatase and protein tyrosine phosphatase activities that regulate both apoptosis and interactions with the extracellular matrix. Recent studies have associated PTEN mutations with tumorigenesis of prostate carcinoma via the Wnt...

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Source

Identifiers

PMID: 15492994
DOI: 10.1016/j.humpath.2004.06.007

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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PTEN mutations do not cause nuclear beta-catenin accumulation in endometrial carcinomas.PMID 15492994Read ↗

Loss of PTEN expression is associated with metastatic disease in patients with endometrial carcinomaSemantic proximity Read ↗

Clinical assessment of PTEN loss in endometrial carcinoma: immunohistochemistry outperforms gene sequencing.Semantic proximity Read ↗

PTEN mutation in endometrial cancers is associated with favorable clinical and pathologic characteristics.Semantic proximity Read ↗

Abnormalities of the APC/beta-catenin pathway in endometrial cancer.Semantic proximity Read ↗

beta- Catenin mutations and aberrant nuclear expression during endometrial tumorigenesis.Semantic proximity Read ↗

Molecular genetic defects in endometrial carcinomas: microsatellite instability, PTEN and beta-catenin (CTNNB1) genes mutations.Semantic proximity Read ↗

The uterine epithelial loss of Pten is inefficient to induce endometrial cancer with intact stromal Pten.Semantic proximity Read ↗

Evaluation of germline PTEN mutations in endometrial cancer patients.Semantic proximity Read ↗

Assessment of the quality and frequency of mutations occurrence in PTEN gene in endometrial carcinomas and hyperplasias.Semantic proximity Read ↗

PTEN mutation, expression and LOH at its locus in ovarian carcinomas. Relation to TP53, K-RAS and BRCA1 mutations.Semantic proximity Read ↗

High frequency of beta-catenin mutations in borderline endometrioid tumours of the ovary.Semantic proximity Read ↗

PTEN mutations in uterine sarcomas.Semantic proximity Read ↗

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