Article
High frequency of beta-catenin mutations in borderline endometrioid tumours of the ovary.
The Journal of pathology - 1 Apr 2006
Oliva E, Sarrió D, Brachtel E F, Sánchez-Estévez C, Soslow R A, Moreno-Bueno G, Palacios J
Abstract excerpt
Some low-grade endometrioid carcinomas arise from a background of endometrioid tumours of borderline malignancy. To determine the molecular mechanisms involved in the initiation of endometrioid carcinoma, the present study investigated whether the genetic alterations reported in these tumours (mutations in PTEN, KRAS, and beta-catenin genes, and microsatellite instability) are already present in endometrioid...
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