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Article

Tyrosine phosphorylation of shc in response to B cell antigen receptor engagement depends on the SHIP inositol phosphatase.

Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 1999

Ingham R J, Okada H, Dang-Lawson M, Dinglasan J, van Der Geer P, Kurosaki T, Gold M R

Abstract excerpt

Tyrosine phosphorylation of Shc in response to B cell Ag receptor (BCR) engagement creates binding sites for the Src homology 2 (SH2) domain of Grb2. This facilitates the recruitment of both Grb2. Sos complexes and Grb2. SHIP complexes to the plasma membrane where Sos can activate Ras and SH2 domain-containing inositol phosphatase (SHIP) can dephosphorylate phosphatidylinositol 3,4,5-trisphosphate. Given the...

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Share to Adaptor Proteins, Vesicular Transport
Share to GRB2 Adaptor Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases

Share to Phosphotyrosine

Share to Receptors, Antigen, B-Cell

Share to Shc Signaling Adaptor Proteins

Share to Src Homology 2 Domain-Containing, Transforming Protein 1

Share to src Homology Domains

Source

Identifiers

PMID: 10570274

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Tyrosine phosphorylation of shc in response to B cell antigen receptor engagement depends on the SHIP inositol phosphatase.PMID 10570274Read ↗

The Src homology 2 domain containing inositol 5-phosphatase SHIP2 is recruited to the epidermal growth factor (EGF) receptor and dephosphorylates phosphatidylinositol 3,4,5-trisphosphate in EGF-stimulated COS-7 cells.Semantic proximity Read ↗

BCR/ABL Directly Inhibits Expression of SHIP, an SH2-Containing Polyinositol-5-Phosphatase Involved in the Regulation of HematopoiesisSemantic proximity Read ↗

The SH2 domain containing inositol 5-phosphatase SHIP2 associates to the immunoreceptor tyrosine-based inhibition motif of Fc gammaRIIB in B cells under negative signaling.Semantic proximity Read ↗

The adaptor protein Shc plays a key role during early B cell development.Semantic proximity Read ↗

SH2-mediated steric occlusion of the C2 domain regulates autoinhibition of SHIP1 inositol 5-phosphataseSemantic proximity Read ↗

SHIP family inositol phosphatases interact with and negatively regulate the Tec tyrosine kinase.Semantic proximity Read ↗

Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals.Semantic proximity Read ↗

Specific tyrosine phosphorylations mediate signal-dependent stimulation of SHIP2 inositol phosphatase activity, while the SH2 domain confers an inhibitory effect to maintain the basal activity.Semantic proximity Read ↗

SH2-containing inositol 5'-phosphatase SHIP2 associates with the p130(Cas) adapter protein and regulates cellular adhesion and spreading.Semantic proximity Read ↗

The SH2 inositol 5-phosphatase Ship1 is recruited in an SH2-dependent manner to the erythropoietin receptor.Semantic proximity Read ↗

The role of SHIP in cytokine-induced signaling.Semantic proximity Read ↗

Mechanism of SHIP-mediated inhibition of insulin- and platelet-derived growth factor-stimulated mitogen-activated protein kinase activity in 3T3-L1 adipocytes.Semantic proximity Read ↗

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